بررسی رابطه پره اکلامپسی با لیپیدهای سرم مادر و بند ناف نوزاد

Background and purpose: Preeclampsia is a medical condition in pregnancy that is determined by hypertension and proteinuria. Among many predisposing factors in pathophysiology of preeclampsia, the role of lipid peroxides is recently emphasized. The aim of this study was to evaluate the association of preeclampsia with maternal plasma and umbilical cord lipid concentration. Materials and methods: A case-control study was done on pregnant women referring to Babol Yahyanejad Hospital, during 2008-2009. Case group included 31 term preeclamptic pregnant women and for control group 31 term normal pregnant women were recruited. All women were 20-30 years of age and were gravida 1 or 2. Total TG, cholesterol, HDL and LDL for plasma and umbilical cord were measured by enzymatic and calorimetric methods. Results: No significant differences were found between women with preeclampsia and normal subjects according to the mean level of triglyceride (291.1  102.8 VS 309.4  114.4), cholesterol (226.3  48.8 VS 234.9  40.6), LDL (119  38.3 VS 123  33.1), HDL (50.1  10.6 VS 51.5  8.1) and VLDL (59.2  20.8 VS 61.5  22.6). Level of lipids in umbilical cord showed abnormal triglyceride level in only one case in the control group. Moreover, the mean level of umbilical cord triglyceride (56.3  32 VS 50.1  54), umbilical cord cholesterol (70.9  22.8 VS 64.4  20.8), umbilical cord LDL (30.9  12.7 VS 26.1  10), umbilical cord HDL (28.7  10.7 VS 30.7  8.6) and umbilical cord VLDL (11.6  6.8 VS 9.9  10.7) were not significantly different between preeclampsia and normal groups (P>0.05). Conclusion: Results showed that there was no association between lipid concentration of mothers and umbilical cord lipids with preeclampsia.